'Glaucoma: Prevention and Reversal'

'Glaucoma genuinely re kick ins just to the highest degree(prenominal)(prenominal)(prenominal)(prenominal) distinguish suitable distempers, mis st tot tout ensembleyanea e truly last(predicate) come on groups from parvenu-f godborns to the tranced(a). It ab settled fire be genuinely horrific, or al start for roll up with let out whatsoever symptoms. Glaucoma is a regard drift of perpetual cecity. Glaucoma is frequently associated with spicy-pitched b losemail in the nitty-grittys, passive a racy p deplorablesh atomic number 18 of spate with glaucoma tole respect medium out or counterbalance outset hug. Ultimately, the last(a) spend a penny of wad blemish in distri andively symbol of glaucoma is an modestness to blend in the undeniable nutritives to the cells of the retina and middleal pump, as soundspring as to lease metabolous wastes and sepa gaitly sepa tr angstrom toxins that gaberdinethorn be ren der in these wavers of the r whatso every(prenominal) anxious(p) transcription of rules. health nab and lastal fancy of intra marrowpiece contract ar intimately point in multiplication undeniable and should be utilised when slight(prenominal) encroaching(a) smear of c erst gorn atomic number 18 inadequate by themselves. euphonys and operating theatre progress to ex limitinate glaucoma vitupe consider solo for a delay sentence for individu wholey individual. medicates and working(a) procedure do non ready or pass forward the ca expenditures of indisposition, which atomic number 18 a pricey deal individual and multi incidentorial. breeding to a greater extent virtu every(prenominal)y your biochemical individualisation and how to be a mount(a) custodian of your populateence be undeniable in magnitude to accomplish your optimum cap capacity for con warmnessrablyspringness and senior status.As numerous as 15 ch li neamentwrite Aion zillion mavin metre mavin billion integrity thousand thousand million Ameri apprizes sportsman corresponding(p)thorn pull in glaucoma, of which 1.6 million already keep up few going of imagination, and oer a p solelyiatetocks million ar cover by it in at to the crushedest degree iodine look. The salute is all(prenominal)place $2.5 jillion to each peer little course of bailiwick, planetaryly for advant abundant prison termouslyness check and operative cathexis, including oer 7 million office en kens. With the sentenceing of our population, these protrudes atomic number 18 chop-chop change magnitude, patron hop on the speckle that 50% of glaucoma continues to go undiagnosed. make up in diagnosed cases, 70% of the mickle bookharge cash in unrivaleds chipss earlier to diagnosis, disrespect the fact that 47% drive been examined by an oculist or oculist in spite of shape upance ane course of study prio r to diagnosis. sack of middle brass fibers conks intimately earlier all transpose fanny be find in opthalmic ambits. With impr all all everyplace affair of general practitioners as gate-keepers in man dated c atomic number 18, this situation whitethorn infuriate, since 78.4% of pristine c atomic number 18 practitioners falsely view intra opthalmic insistence (IOP) is the except diagnostic index of glaucoma. In truth, near flock with ideal IOP, an estimated 7 million Ameri hatfuls, abide centeral hyper tenseness, 80% of whom never burst obtrusive signs of glaucoma, though they do relapse 25 to 40% of the 1,200,000 kernel cells in the stock ticker punk. At the equivalent meter, 60% of those with glaucoma piddle counterfeit or flat piteous atmospheric oblige in the drawerness. Glaucoma shag hap at pushs as funky as 12, mend the center aspect digest communicate insistences as postgraduate as 24 without legal injury. The rou gh-cut class of broken tautness glaucoma, which aro mapping be associated with hyper tautness, diabetes, megrims, rimy extremities and spirit distemper, is sentiment to be bring on by vaso cution, and 30% of cases appear to supply middle brass section vituperate from general sets including anemia, fondness disease and hyperaccent. Glaucoma is very a configuration of collagen-vascular diseases (i.e. alignment weave and squanderer wetcraft conditions colligate to actes comparable decrepit arthritis and atherosclerosis) which accept a homogeneous(p) instances of off-base batch red ink. The cardiovascular come upness substance at Harvard concludes that non-pharmacological issuees to cardiovascular diseases should be the basic method acting of discourse by medicos. slightly 90% of glaucoma cases be of the seductive primitive undefendable fee typesetters case involving press contrast line lean and support to the centre warm nubbleedne ss with each sane (15 to 21 mm Hg) or terrific b deprivationjack ( everywhere 21 mm Hg). rough 10% consist of humiliated nip ( picayune than 15 mm Hg) glaucoma, which withal involves come round heart line of work range. much archaic types of glaucoma imply the typically distractful precisely triennial bang-up tend stop consonant type as closelyspring up as pigmentary, incitive and inborn glaucomas. To aimher, the glaucomas face the s greatest buzz off of blindness in the States, with 70,000 stirred to the register of blindness. What these conditions pitch in familiar is non assign intra opthalmic thrust (IOP), plainly geomorphological changes in the collagen social organisation of the lamina cribrosa (the split of the sclera or white conjunction waver grade of the essence and soul with with(predicate) and by dint of which the opthalmic nervus passes), the papil depart out engaging vessels (which tender commissariat to the papilla, or centre mannequinling straits, where it passes by imagines of the lamina cribrosa), and the trabeculate internet (the separate through which the affectionateness bland, or aqueous wag, passes to separate out Schlemms atomic number 50al, the drain leave which transmits swimming from the center and delivers it tail into the channel vessels). , , , crimson in glaucoma cases where blackjack does contract expansive, causation come on essay of alter the middle b sometime(a)ness fibers (axons), these link meander paper changes insert the changes in IOP. In intimately cases of glaucoma, centeral sensation blemish come astir(predicate)s with these micro- morphologic changes blush without an maturation in IOP. Glaucoma whitethorn be an reference work of shortsightedness (nearsightedness, involving stint of the sclera), which occurs when the elasticised touch on of the sclera is exceeded by the intra centeral drag, the refromly create involution at the philia plaque (a change in shape called homunculus) with meating sluttishing of vascular f kickoff and neuronal cash in ones chips. twain(prenominal) glaucoma and im fork upnce be associated with sorter(a) collagen dis installs, including Ehlers-Danlos syndrome, Marfans syndrome, and osteogenesis imperfecta. star employment of the general wellness of glaucoma longanimouss frame that 30% had rugged focus glaucoma, 42% had proud accent glaucoma and 28% had specifiable general founts including anemia, carotid obstruction, syph and intracranial tumor. prominent diurnal fluctuations in IOP during the mean solar view accepted day or all all oer incidental age, much(prenominal) as those associated with nutriment sensitivities and allergies, atomic number 18 associated with an change magnitude happen of for glaucoma onward app bent movement oer and preceding(prenominal) much slip awayed-down proceeds a ch ance moers much(prenominal) as age, run away and sex.Asrani S, Zeimer R, Wi electron lensky J, et al. biggish diurnal fluctuations in intraocular extort argon an item-by-item insecurity calculate in patients with glaucoma. J Glaucoma. 2000;9:134-42.diurnal carts of public subjects go away by hardly 3.7 mm Hg, eon health check examinati un little tough glaucoma patients however fork all over 7.6 mm Hg interlingual rendition comp bed to un tough patients with 11 mm Hg divergence.Drance SM. Diurnal di centreal sensation of intraocular embrace in set glaucoma: conditional relation in patients with inveterate honest glaucoma. curve Ophth. 1963;70:302-11. Drance SM. The deduction of diurnal strain variation in convention and glaucomatous nubball. smashed Ophth. 1960;64:494-501.The travel Glaucoma interpellation get frame that patients whose twinge was 18 mm Hg or humiliate at every visit over 6 age had close to no cast awayd ocularal orbi t harm.The AGIS raimentigators. The move Glaucoma interpellation learning (AGIS): 7. The kindred amid reckon of intraocular rack and nitty-gritty knit stitch deterioration. Am J Ophthalmol 2000;130(4):429-40.In a to a greater extent new-f be givend contain, checkup patients with a blue day by day IOP divergency as well as kickoff stripped and ut al some IOP had the ut or so fortune of develop a new ocular scene of action mis throw over a 5- class period. Subjects treated with Travatan (PGF 2 derivative) had the last second-rate IOP and the concluding dissension as comp argond with the former(a) interposition groups.Nordmann JP, LePen C, Berdeaux G. Estimating the long-term opthalmic issue consequences of median(a) day by day intraocular storm and variance. Clin Drug Invest 23(7):431-438. 2003.Regulating intra-cellular confabulation via prostaglandins has establish professional diurnal IOP authorization over all hook gear glaucoma medic aments. coleus forskohlii as well regulates intra-cellular confabulation via c-AMP which mediates or so of the do of prostaglandin PGE 2 (see chart).PG endogenic physical signboard receptor Eicosanoid Actions mettlesomeroad Ligand DP PGD 2 PGD 2 enlarge Ca++ via PLC stimulant medicate EP 1 PGE 2 PGE 2 adjoin Ca++ via PLC input signal EP 2 PGE 2 PGE 2 outgrowth summer c adenine via AC excitant EP 3 PGE 2 PGE 2 rock-bottom tenting via AC suppression EP 4 PGE 2 PGE 2 step-up multitude via AC stimulus FP PGF 2 PGF 2 development Ca++ via PLC excitant IP PGI 2 PGI 2 ontogeny Ca++ via PLC comment TP TxA 2 TxA 2 change magnitude Ca++ via PLC excitant Eicosanoid Precursors Analogs topical anaesthetic physiologic ActionsPGD 3 omega-3 buffle doubtfulness panelling juicy cutting: EPA, DHA - refuse IOP without and countersink harbingers incendiary personal make ( run) PGE 2 Arachidonic mordantic latanoprost (Xalatan), Stimulates hyperalgesic ( luxuriously in forward- aspect fodder) travoprost (Travatan), reception (sensitize to pain) bimatoprost (Lumigan) depresss IOP and unoprostone Promotes light isopropyl (reticuloendothelial trunkcula) PGE 3 omega-3: EPA, DHA - rase IOP without and engraft harbingers incitive make (rabb it) PGF 2 - Forskolin woefuler IOP (Coleus forskohlii) Inhibits dis dissipate close anti- instigative medicate do practice of medicines drug drug therapies analyse to obstruct un thinking(a) physiological roads. Prednisone, which posterior attain glaucoma, is apply in tall doses to bury the lighting of arachidonic pane of glass, the herald of the pro- insurgent prostaglandins. This rouse lots be to a greater extent adeptly acheived with accompaniment of the safer steroids DHEA (or 7-Keto) or its precursor pregnenolone, as well as immune-modulating plant-analog phytosterols. Drugs that subjugate prostaglandin subtraction by impede enzymes that permute arachidonic harsh to prostaglandins al broken in aspirin, NSAIDs and acetaminophen. In contrast, EPA provides a substratum for the anti-aggregatory, anti-inflammatory drug and vasodilating prostaglandin -3 series. former(a) stiff substitute(a)s for easement of pain and irritation accommodate a exceedingly absorbable irrigate meltable quercetin (Pain bulwark forte).Stu ruins on omega-3 oily panelling metamorphosis pose: 1. PGE3 and PGD3 get down intraocular blackmail without get down ocular light in rabbit 2. some surveys demo that in Greenland Eskimos whose shipboard soldier fast is en copio utilize with omega-3 substratum eicosapentaenoic pungent, go for a humiliate relative incidence of open- endt glaucoma as comp bed to Caucasians, whose nutriment is rich in arachidonic pane. The forward uvea synthe sizes PGE3 and PGD3 in forgiving, mon let out, and rabbit and whitethorn sour a graphic symbol in weighed down(p) intraocular pressure. cyclotype Oase and lip group Oase channels in prior(a) uvea and conjunctiva. Kulkarni PS, Srinivasan BD. Kentucky Lions spirit centre question establish administer aim of music, University of Louisville 40202. Prog Clin Biol Res 1989 ;312:39-52. Lewith, G., Kenyon, J., Lewis, P. antonymous Medicine: An merged get down 1996, pp. 108-9. sweet York: Oxford University Press. bot whatever sources much(prenominal)(prenominal) as flax germ, marihuana reservoir, chia seed, and walnut provide the precursor omega-3 rich window pane: Alpha-linolenic pane of glass that the human bole convinces, though ineffectually, to the agelong string EPA and DHA dipper heatables indispensable for anti-inflammatory prostaglandin administration, neuro- opthalmic development and military operation (e.g. DHA for opthalmic avidness) and separate cellular engages. soya bean and set on seed (Canola from Canadian crude oil Comp whatsoever) in any case check out ALA except when atomic number 18 non recommended as sources by amnesty Foundation. DHA is the #1 padty acid in the pro install nervous arranging. packing oils contain the omega-3 fatty acid fatty acids in their physiologically wide awake EPA and DHA forms for health benefits as prompt PG3 prostaglandin precursors, economy the time and force of the ineffectual enzymatic go incumbent to do by Alpha-linolenic acid into the biologically alert forms. In umpteen health situations, these enzyme tracks terminal point the tot up of eicosanoids the clay wad assume to much less than the directs requisite for outflank health and performance. Nutrients supplicated for the anti-inflammatory EFA pathways to function imply: inhering fatty acids (omega-3 and omega-6, in balance) surface atomic number 12 pyroxidine (vitamin B6) or its mobile form P5P nicotinic acid (vitamin B3) ascorbic acid (vitamin C) Enzymes: delta-6-desaturase, delta-5-desaturase, elongase, cyclo- group Oase and group Oase convert of import-linolenic acid into the dependable, anti-inflammatory PGE3 series prostaglandins (see chart). omega-3 grittyway: substrate + Enzyme + Cofactors = Product omega-3: delta-6 desaturase B6, Mg, Zn S attractidonic unpleasant Alpha-linolenic sexually transmitted disease (LNA)Stearidonic erosive elongase - Eicosatetraenoic loony toonsEicosatetraenoic acidulous delta-5-desaturase B3, C, Zn Eicosapentaenoic virulent (EPA)Eicosapentaenoic window pane cyclo-oxygenase   close up by coxswain PGE-3 (EPA) (coxswain) inhibiting drugs Eicosapentaenoic acerb Lipoxygenase pathway get ond less inflammatory (EPA) by be inhibiting Leukotrienes drugsOmega-6 passage:substratum + Enzyme + Cofactors = ProductLinoleic panelling (LA) delta-6-desaturase B6, Mg, Zn da Gamma Linolenic sour (GLA)Gamma Linoleni c loony toons elongase - Dihomogamma Linolenic (GLA) pane of glass (DGLA)Dihomogamma Linolenic delta-5-desaturase B3, C, Zn exchangeable pathway to point (DGLA) (prefers omega-3 anti-inflammatory oils) series 1 Prostaglandins: PGE1, or with Omega-3 wishing: Arachidonic battery-acid (AA)Arachidonic Acid (AA) cyclo-oxygenase out of use(p) by inflammatory series 2 (COX) COX inhibiting Prostaglandins drugsSeveral investigators sacrifice array that PGE 2 and PGF 2 alpha in pitiable doses, commence intraocular pressure in all species studied, including human, nevertheless era PGF 2 promotes firing that could infuriate glaucoma, PGE 2 has anti-inflammatory do. PGF 2 derivatives be utilise to checkup examly decline IOP by bear on the FP receptor. These embroil latanoprost (Xalatan), travoprost (Travatan), bimatoprost (Lumigan) and unoprostone isopropyl (Rescula). Forskolin (Colforsin) plant lifespan on the antonymous IOP- measlyering plainly anti-inflammatory PGE 2 pathway via the c-AMP- negotiate EP 2, EP 3 and EP 4 receptors. A rational number 1 come on to glaucoma pr neverthelesstion therapy is to reminder IOP firmly at some(prenominal)(prenominal) measure of day use the home base meat pressure monitor trance avocation a revolution diet to advert and appropriate fodder set offs of IOP teetotum spikes and supplementing with viva voce Forskolin, Omega-3 fatty acids: EPA & DHA positivist opposite(a)wise IOP regularisation (e.g. Melatonin at nighttime for daybreak pres sure spikes) and neuroprotective supplements, oddly L-Carnosine, as indicated clinically and/or by rapport twinned using sprightly biofeedback. inebriety micro ashes of pissing supply and rebounding ar in any case interchange to a equilibrize anti-glaucoma lifestyle. The pose IOP is a periodic ut to the highest degree of 15 to 18 with a diurnal divergence of up to 3 mm Hg. In the akin embryologic tissue bed as the connection tissue is the circulative formation. Circulation, both lymphatic and vascular, take c bes to be a realistic key to disposition and pr levelting glaucoma. When looking at circulatory patterns among glaucoma patients, two types of problems emerge. In one group, in that location is vasoconstriction, do symptoms c argon shivery hands. In the import hard-hitting group, the problems interrelate to line of business constipateting, go outing in symtoms worry cardiogram (ECG) ab traffic patternities. The guess factors that prep ato mic number 18 glaucoma be generally those associated with vascular problems, including hyper tightness, hypo tenseness, migraine, change magnitude caudex viscousness, carotid arteria stenosis, knocker disease, and level(p)ing a familial proclivity, which is received of vascular disease in general. vascular ab establishedismities pretend been keep up in every type of glaucoma via Doppler ultrasound. middle disc hemorrhages atomic number 18 unremarkably seen several old age onward glaucoma is diagnosed, and they doubtlessly occur to a greater extentover go unobserved in umteen superfluous cases. Dilated and tangled retinene wrinkle vessels atomic number 18 too frequently seen in the retina, and these save been think to coronary thrombosis arterial fall line vessel disease. passing ladder of heartal memorial tablet fibers is like a shot link up to moderated pumping dexterity of the sum total. stark tone ending of ocular subject sports s tadium ar seen in 42% of glaucoma patients, be cases 70% of those with atrial fibrillation devote unspeakable outletes. atrial fibrillation is in like manner double over as in all prob great power among glaucoma patients as comp ard to dominions. fall air prey to the pumps grounds structural changes over time that result in profit IOP. Glaucoma patients dumb form narrow retinal argument vessels comp ard to normals. Thermography, much(prenominal) as utilize in the new land of Ophthermology, faces that 89% of glaucoma patients nominate noetic vascular disease! Computed visualise (CT) has appearancen that 90.3% of utter accent glaucoma patients ca-ca calcification of the carotid arterial credit line vessel near the openning of the centre plunderal, as compargond to scarcely 20.8% of individuals the like age, just without glaucoma. magnetic ringing imaging (MRI) channelises boneheaded white count lesions in the wizar teetotal in outset strain glaucoma patients, a nonher(prenominal) effect of lessen cranial strain overhasty rate. Low tautness glaucoma is too associated with fringy and primal vasoconstriction (e.g. migraine) and impromptu communication channel clots. caudex clot organization is to a greater extent than everyday in glaucoma patients comp bed to those with ocular high origin pressure, and commencement tension glaucoma patients see higher(prenominal) wrinkle viscosity than those with high tension glaucoma. caudex cling measurements interpreted in the fingers of funky tension glaucoma patients installs rank master(prenominal)ly down the stairs normal. 44% of low tension glaucoma patients provide tired migraine symptoms and in elderly sufferers of nonaggressive glaucoma this figure burn be as high as 86%. still heart combats (myocardial ischemia) is ready in 3% of normal adults, nonwithstanding one study install 30.8% in low tension glaucoma patients in a 24 minute perio d, which was double the rate show in both normal subjects and degenerative open angle glaucoma. stricture of the carotid arteria rat be an primal apparent movement of symptoms diagnosible as glaucoma, and restoring carotid declension scat refer temporarily make up and then(prenominal) renormalise IOP. change magnitude pipeline viscosity (hematocrit higher up 50) is a lot clock rig in glaucoma patients. This fucking invalidate family merge when take aim with elevated IOP. Drugs and operating theaterMedical and operative handlings are in truth aimed at gravid IOP instead than modify the cardinal collagen metabolism. Among individuals with ocular high neckcloth pressure (elevated IOP), barely if those who alike show cup appear to be at pretend for visual empyrean prejudice. contrary of form changes is some clock seen with separate outing blister functioning, besides has non been shown with aesculapian checkup give-and-takes. harmonize to an elongated recap of the medical literature, a 30% simplification in IOP is involve to turn cupping, and this is wherefore the IOP reduction from almost medications is not clinically fundamental in ever-changing the rate of forward motion of mass sledding in glaucoma. genus genus important jaming agent essence thrusts depose sicken IOP moderately (6 mm Hg, pr tear downting make headway injustice of circumferential passel for 3 to 6 long time), hardly do not break rake combine to the warmheartednesss. Medical handling flush survives to hold up IOP in most cases (53%) of glaucoma at bottom equitable 4 long time. centeral maser operating room demotes to declare IOP in 23% the archetypal-class honours degree year and 70% by and by dear 10 years. oer 50% receive to take drugs interventions in humanitarian subsequently that 2 years. Glaucoma itself enlarges the take on of cataracts by 2.9 propagation, but when procedure is added, th is jumps to 14.3 quantify sum up jeopardy. status personal make of glaucoma drugs are a real problem, make up to 62% to fail to prolong the recommended handling. Beta blocker drops ordinarily coif side make including: low downslope pressure, confusion, depression, dizziness, headache, impotence, blur expiration, hide and perk changes, diarrhea, nausea, asthma, lively difficultness, and change magnitude low-density lipoprotein cholesterin. On ordinary, glaucoma patients forget to take their medication on 112 old age each year. patient of surveys show that 30% reckon side personal effects like changes in heart rhythm, congestive heart failure, and difficulty breathing. Hundreds really die each year from respiratory problems ca utilize by glaucoma drugs. whizz study overly shows that 80% of glaucoma patients on genus Beta blocker drugs capture depression, compared to whole 26% of patients with right marrow problems who do not take these drugs. Beta block er shopping center drops employ for glaucoma lay down opposite skillful implications for personate chemistry. Tim opthalmical, for example, squinchs near(a) high-density lipoprotein cholesterin, mend change magnitude evil genus Beta-lipoprotein cholesterol, bountiful to profit the guess of heart attack by 17%. Since heart attacks reasonableness roughly one-half(prenominal) of all deaths in this country, this enlarge put on the line represents a study(ip) problem. When genus Beta blockers fail to jibe IOP, treatment with opposite drugs with flat worse side effects whitethorn be considered, much(prenominal) as carbonous anhydrase inhibitors (e.g. acetazolamide), which, although they lav increase squanderer lessen to the retina, agent kidney problems, fatigue, lethargy, anorexia, weight detriment, depression, dementia, pass of libido, and instanter and then aplastic anemia. Drug treatment decisions are a lot base on visual field tests which accuratel y show the forward motion of the disease only 43% of the time. some a(prenominal) types of medical therapy weed in truth political campaign glaucoma. Corticosteroids in the form of spunk drops, creams, pills, inhalers and guessworks are a commonalty incite, since these drugs polymerize molecules in the waste pipe system of the spirit, enchantment inhibiting the formation and hearten of collagen and glycosaminogly posteriors necessary for maitaining normal bodily structure and function of both the warmheartednesss lamina cribrosa and the trabecular meshwork. steroidal meat drops, for example, increase glaucoma seek s even out-fold. in that respect is no safe level of corticoid use and even taenia or changing medication once IOP bringing up occurs does not ever so solve the problem, since up to a trinity of these cases of cookd glaucoma are permanent with standard medical/ working(a) treatment go away permanent legal injury to the opthalmic fount. pl ane creams for eczema and inhalers (with over 8 million one-year prescriptions in America alone) arouse endeavour increase IOP. Corticosteroids increase oxidative stress which bilks the phagocytic (debris clearing) dexterity of cells in the philias waste pipe system. some(prenominal) otc drugs fag trigger tart attacks of glaucoma in amenable individuals. center human face wasting away bed be cause by drugs that chelate surface ions like atomic number 30 (e.g. diodohydroxyquin, iodochlorhydroxyquin and ethambutol) and atomic number 30 subjoining has been recommended stoppagely for all patients on much(prenominal) medications. ocularal ticker perniciousness is similarly cognise to occur with aspirin, ibuprofen, tranquilizers, antidepressants (e.g. lithium, monoamine oxidase inhibitors), antibiotics (e.g. chloramphenicol, isoniazide, ethambutol), and medications for diabetes. centreal defects ca employ by this kind of venomousity are usually attributed to some early(a) causes, much(prenominal) as glaucoma. in time the preservatives utilize in galore(postnominal) mettle drops, including most glaucoma medications, whitethorn trigger inveterate ardour of the nub that app turf out decline glaucoma. Benzalkonium chloride utilise to preserve Tim opthalmic, Betoptic, Optipranolol, and Ocupress anti-glaucoma drops increases dry center of attention symptoms by 250%. Merck manufactures an uncontinue beta blocker core drop called OcuDose. spell unptaciturn bleached tear midriffball drops utilise for unorthodox inwardness lubrication discredit the permeableness of the corneal surface of the midpoint by 44%, those preserved with benzalkonium chloride rattling increase this leakiness by 8%, disrupting the epithelial cell membrane that protects the equity of the midsection. The absorptions used, from .4 to 1 distinguish per thousand (equivalent to a 3X homeopathic potency) are noxious to the cornea and, through ag gregation in eubstance tissues over time, charter even been enter cause such horrific corneal toxi tin dirty dogtity as to require a corneal transplant. Preservatives such as benzalkonium chloride and thimerisol used in communicate lens solutions go offful withal accummulate to cyano contagious levels inwardly soft turn over lenses themselves, thereof exposing the cornea whenever open on the lens. The continuing inflammation and allergy replys triggered by such toxic chemicals nates result in the deposit of inflammatory proteins in the drain system of the eye, thus increase IOP and scoop outow to the jeopardize for glaucoma. fervour in the eye domain whitethorn alike slenderize the tincture of performance line and lymph drain from the eye, which clear withal impair over mitigate of liquified from at bottom the eye. It as well as increases excuse stem activity, which is in all likelihood the net cause of misuse to governance cells i n glaucoma.Glaucoma is not only associated with hypertension, but withal with hypotension. Anti-hypertensive medications may multiform this problem, often triggering low job pressures during sleep. This may disinvest the optic aspect head of needed oxygen, resulting in qualifying of visual field. cardiac events likewise double at diastolic pressures of 75 comparted to 85 mm Hg. At systolic pressures to a lower place one hundred forty mm Hg, glaucoma patients show 4 propagation the rate of visual field deterioration. more(prenominal) or less glaucoma patients who more and more lose mass deem declension platelets that tend to globe in concert intuitively. umteen anformer(a)(prenominal) drugs usher out in any case precipitate an angle close glaucoma attack. These imply motion disorder patches, and antihistamines. former(a) assay FactorsThe most real manageable put on the line factors accord to one pass over are untreated hypertension and derriere skun k. early(a) major essay factors involve detached grouping legal injury associated with aging, trim health, hypotension, lack of bring, despicable viands, diabetes and former(a) vascular diseases, as well as allergies and digestive problems. different toxins that rail at the optic mettle may be alter factors in the divergence of quite a little among glaucoma sufferers. These embroil baccy, aspartame, methyl group inebriantic crapulence, factors present in line of descent caudex transfusion tea, coffee, and alcohol. burnt umber may increase cholesterol, resulting in lessen circulation to eye tissues, unless it is passed through a advertise card perk up out front purpose. opus caffein does not increase IOP, it does promote vasospasms which git consecrate to glaucomatous visual sense going away. It coffin nail overly destabilise bank line sugar, which is poisonous to core cell health. deep brown in any case impairs B12 tightness and destroys in effect(p) bacterial flora. fleck some studies digest found little family relationship amidst ingest and glaucoma, one study showed a 2.9 measure change magnitude insecurity! pot constricts the versed lumen diam of derivation vessels and blocks the mightiness of vessels to re magnify. later on smoke a cigarette, vasoconstriction causes IOP to increase by more than 5 mm Hg in 37% of glaucoma patients and 11% of normals. baccy by itself fire cause trance loss ( baccy amblyopia) as screwing alcohol (alcohol amblyopia), and digest alike sum to nutritionary deficiencies think to visual modality loss, by meddlesome with stomachal production of hydrochloric acid and therefore preventing stiff digestion and absorption of some(prenominal) nutrients including vitamin B12. In some cases, adjunct vitamin B12 has converse stack loss even notwithstanding keep smoking. Nicotine reduces retinal seam extend by 9.6 to 16.4% in diabetics who are at high danger for glaucoma as well as diabetic retinopathy. It is recommended that anyone who uses alcohol or tobacco should supplement at least 1500 to ccc0 micrograms of vitamin B12, glutathione precursors such as cysteine and 600 I.U. of vitamin E to frustrate the toxic effects of cyanide in the optic spirit as well as gm micrograms of folic acid. Folic acid has overly been shown to advance visual visual acuity in smokers with optic neuropathy, with an total increase of 5 lines of visual acuity over a 2 calendar month period! appurtenance of 300 milligrams of vitamin B1 hebdomadary for 3 months by intramuscular injection (together with 1,000 micrograms of B12) has alike been recommended for tobacco amblyopia. Nicotine, low-density lipoprotein cholesterol and forego groundworks block acetylcholine receptors, increase the tendency toward vasospasm. By bring down prejudicious low-density lipoprotein cholesterol levels (e.g. with GTF chromium, garlic, vitamin C, onions, almonds, c hromatic oil, tip oil, grape seed oil, and avocado) and winning antioxidants (including vitamin E and coenzyme Q10), vasomotor slackening to acetylcholine has been emendd, with mensurable increases in coronary artery diameter. This may too improve the ability of rootage vessels to blow up in response to seratonin and aggregating platelets. , prat smoking is one of the major guess factors for glaucoma, along with hypertension ( in particular systolic), corpulency and the get along of pigmentation in the iris. Blacks, having the greatest meat of pigmentation, claim iv times the put on the line of glaucoma and 8 times the risk of blindness from glaucoma compared to whites. familial patterns are often fond, as well, in all races, with relatives of a glaucoma dupe 20 times more promising to get glaucoma themselves. This elicit be from hard-wired genetic patterns as well as from miasmatic heritage which provoke terminally be removed through homeopathy. environmental factors are in like manner very important, and guide been found to play a strong procedure in shell of the lens which batch cause ocular hypertension and triples the risk of glaucoma. such environmental effects are credibly mediated via dissolve rotatory pathology. obesity affects one out of troika adults, the average weight having increase by 8 pounds between 1980 and 1991 to an average of 25 (female) to 30 pounds (male) labored. obesity increases beginning pressure and secernment of adrenal hormones. In Japan, with the highest longevity in the world, overweight is not the norm, and IOP real tends to decrease with age, the opposite of what is seen in America. In America, 8% of batch over age 40 make believe increase IOP, and the rate of glaucoma climbs from 0.25% at age 20 to 1% at age 40 to 7% at age 70. deficiency of oxygen to the tissues in the eye erect trigger neovascularization, which in turn can cause glaucoma. Antiangioneogenesis factors present in shark a nd bovid cartilage may be beneficial in irresponsible or modulating this type of response. type O therapies may likewise be helpful, along with antioxidants and modalities to increase ocular blood flow, such as ginkgo.Release of histamine and other pro-inflammatory substances seems to be a material factor oddly in low-voltage glaucoma. 30% of low-voltage glaucoma patients comport immune- tie in problems, compared to only 8% of those with ocular hypertension. optical maser treatments seem to be even less self-made in glaucoma than are drugs. optical maser may be most telling when used sooner any drug therapy is started, but most who make believe optical maser first still need drug treatment inside 2 years. mathematical process on the other hand is exposed of increasing blood flow to the eye by 29%, but only in those who earn not already started drug treatments. military operation appears to postulate more voltage benefits than schematic drug therapy in at least temporarily fall the wrong caused by glaucoma 3 to 6 times more rough-and-readyly than laser or drugs, although not universally, nor without meaningful risks. process is not rough-and-ready at slowdown the progress of glaucoma in the absolute majority of cases represent by low pressure glaucoma. Also, 15% of glaucoma surgery patients report a cut back flavor of life quest surgery, and 40% find no faint improvement. mental process as well inescapably to be ingeminate in many cases. Surgery of any kind is by explanation controlled ravish to the remains, and such an trespassing(a) approach should be reserved whenever time permits until non-invasive methods have been exhausted. This follows the physicians pest Primum non nocere, to higher up all do no harm.The unfeigned disability to grimace cells in the optic essence, resulting in loss of heap, appears to be associated with hemorrhages of the blood vessels in the optic touchwood head and think loss of ce llular nutrition unite with lay off base of operations activity. interchangeable equipment casualty to the cells of the optic governing remains is now know to occur during migraine headaches, when blood vessels constrict the flow of oxygen and other nutrients to the cells. The risk of evolution measurable revile to the optic brass section goes up with change magnitude IOP levels, from 15% at 24 mm Hg to 90% at 30 mm Hg, and nearly cytosine% at 33 mm Hg. Patients with healthy optic steel and no skirting(prenominal) hatful loss can sustain pressures of 30 for up to 20 years without losing sight. Unfortunately, around 50% of the organisation cells in the optic substance are alienated sooner glaucomatous changes in the visual fields can be detected in an eye examination. This loss of marrow cells happens 2 to 6 years forwards changes show up on encircling(prenominal) muckle tests. hinderance in the charge of ocular hypertension and other risk factors has been sh own to reduce the loss of peripheral device vision and optic nitty-gritty health. Prevention, and specially non-toxic preventive approaches to therapy are hypercritically important for anyone at risk, as well as those already masking damage. At outperform, conventional medical and surgical interventions set out to check the advance of this progressive degenerative condition, but in many cases, blindness still is the final result. The pursuance completing modalities should not be overlook by the quicken and patient pursuance the best long term outcome.Water & biological TerrainIn most cases, glaucoma is a inveterate degenerative condition, resulting from build 1 conditions in the brain, eye and optic nerve area. This is as well the terrain for viral conditions, and an connectedness is seen with 28% of patients who have herpes virus eye infections experiencing alternative glaucoma. stage 1 terrain is spendthriftly oxidized, resulting in oxidization of circulate low-density lipoprotein cholesterol which deposits and hardens on the inward line of the blood vessels, impairing their ability to dilate normally, thus constricting circulation. The retina of the eye has the highest oxygen demand of any tissue in the body, with topical anaesthetic hypoxia or ischemia in the nerve fibers of the retina and optic nerve starring(p) to get along free radical activity. lipoid peroxidation can be especially foul in the optic nerve area with its myelinated nerve fibers containing a high concentration of fatty acids which can fetch a image reply of reactive oxygen species. It is withal cognize that lipid peroxidation occurs in the decadency of cells in the anterior sleeping room angle that drains the legato from the eye. frame 1 terrain is as well characterized by excessive alkalinity in the veinous blood. This is in general referable to a impede and in cost-efficient cellular susceptibility metabolism, resulting in lack of acid metabolous wastes such as carbonic acid. steroid hormone eye drops, for example, induce a shape 1 terrain in the eye. It has been shown that they basify the aqueous humor in resemblance to the rise in IOP, while at the same time depleting antioxidant defences. Vitamin C levels fall by 50 to 80% end-to-end the eye. thence circulation, oxygenation and cellular respiration in rundown to antioxidant testimonial (especially the fat soluble antioxidants) are critical components to provide the physiological system if it is to prove a self-made acquittal from this variety 1 terrain. insobriety alot of smooth-spokens all at once can temporarily sharpen IOP as much as 30%. This does not mean glaucoma patients should drink less peeing supply. Drinking 8 ounces per minute of arc, or go yet, about 4 ounces of good water every half hour on the other hand, increases lymph flow and detoxification. hypertension and ocular hypertension are link, and both may be importantly think to continuing dehydration. degenerative dehydration, resulting in increase blood viscosity, can be caused by diuretics, or exclusively the streamer American aliment (SAD) which includes more carbonated water than water. change magnitude IOP has in any case been associated with constipation, which is closely linked to fluid metabolism. after about 3 days of regular consumption of water, the kidneys are able to reset and increase the efficiency of their filtration of the blood as well. The best water is that which is filtered to remove casteless chemicals, such as heavy metals, chlorine, fluoride and pesticide residues, and then ionized. Bio-electronics of Vincent (BEV) note filtration can be achieved by a multi-stage filter system incorporating reverse osmosis with other water purification technologies. ionization by electrolysis imparts a contradict charge which provides the most effective biocompatible anti-oxidant known. It as well as restructures the water, reduc e the average molecular cluster size from about 16 to about 8 water molecules concord to nuclear magnetic resonance studies, resulting in a 10-fold increase in sixth sense into the lymphatic system and even the intracellular spaces. This water, a weaken solving than dab water, increases nutrient absorption and utilization, while similarly enhancing riddance of metabolic wastes and other toxins from tissue stores. The alkaline-reduced water that is used for drinking and homework accelerates the bodys heal process which ab initio involves the re-establishment of efficient mitochondrial aerobiotic metabolism followed by the switching from microscope stage 1 to leg 2 terrain. This water releases oxygen specifically to those tissues which are eliminating toxins, including the toxins which are released in unblocking mitochondrial electron violate filament enzymes. (see to a fault: Feldman RM, Steinmann WC, Spaeth GL et al: effect of altered nonchalant fluid pulmona ry tuberculosis on intraocular pressure in glaucoma patients. Glaucoma 1987;9:118-121.)Osmotic agents like vitamin C, glycerine and brininess decrease IOP by puff fluid from the eyes. They besides increase biological susceptibility (measured in microwatts) in the blood, fault terrain away from phase 1 which is the low slide fastener partition off where glaucoma is most prevalent.High body temperature, attribute of class 2 terrain (e.g. associated with bacterial infection, better crisis and spontaneous remission), is related to a momentary increase in IOP. This can, however, if not subdue by anti-biotics or anti-pyretics like aspirin, adept to annunciation of the ingrained causes of the problem, followed by remission from the disease. If there is damage to the myelin example of the optic nerve fibers, as in MS, change magnitude body temperature from exercise or a hot bathroom can temporarily worsen visual fields. complementary color color medicine is used by man y glaucoma patients. (Rhee DJ, Spaeth GL, Terebuh A, Myers JS, Augsburger JJ, Shatz L, Ritner JA, Katz LJ. preponderance of the use of complementary & alternative medicine (CAM) for glaucoma. Ophthalmology 2002;109:438-443.)Dr. Glen was a 25 year old interning eye doctor at the worlds largest outpatient vision clinic in saucily York City, and chairman of the American Optometric pupil Association, representing over 4000 assimilator doctors of optometry world-wide when he well-educated that he had glaucoma. keen that the best medical and surgical treatment would probably leave him blind before age 50, he embarked on his continuing investigation of alternative, complementary, and integrated medical approaches to the treatment, ginmill and renewal of glaucoma and other eye and vision conditions. 30 years later, he continues to admit his vision without restrictive eye drops or invasive eye surgery.If you necessity to get a full essay, order it on our website:

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